Origin and evolution of spliceosomal introns

IB Rogozin, L Carmel, M Csuros, EV Koonin - Biology direct, 2012 - Springer
Evolution of exon-intron structure of eukaryotic genes has been a matter of long-standing,
intensive debate. The introns-early concept, later rebranded 'introns first'held that protein …

Viruses and mobile elements as drivers of evolutionary transitions

EV Koonin - … Transactions of the Royal Society B …, 2016 - royalsocietypublishing.org
The history of life is punctuated by evolutionary transitions which engender emergence of
new levels of biological organization that involves selection acting at increasingly complex …

Rice sHsp genes: genomic organization and expression profiling under stress and development

NK Sarkar, YK Kim, A Grover - Bmc Genomics, 2009 - Springer
Abstract Background Heat shock proteins (Hsps) constitute an important component in the
heat shock response of all living systems. Among the various plant Hsps (ie Hsp100, Hsp90 …

Origin of spliceosomal introns and alternative splicing

M Irimia, SW Roy - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
In this work we review the current knowledge on the prehistory, origins, and evolution of
spliceosomal introns. First, we briefly outline the major features of the different types of …

Mystery of intron gain: new data and new models

SW Roy, M Irimia - Trends in Genetics, 2009 - cell.com
Despite their ubiquity, the mechanisms and evolutionary forces responsible for the origins of
spliceosomal introns remain mysterious. Recent molecular evidence supports the idea that …

When good transcripts go bad: artifactual RT‐PCR 'splicing'and genome analysis

SW Roy, M Irimia - Bioessays, 2008 - Wiley Online Library
Gene and intron prediction are essential for accurate inferences about genome evolution.
Recently, two genome‐wide studies searched for recent intron gains in humans, reaching …

MitoCOGs: clusters of orthologous genes from mitochondria and implications for the evolution of eukaryotes

S Kannan, IB Rogozin, EV Koonin - BMC evolutionary biology, 2014 - Springer
Background Mitochondria are ubiquitous membranous organelles of eukaryotic cells that
evolved from an alpha-proteobacterial endosymbiont and possess a small genome that …

Disparate Dynamics of Gene Body and cis-Regulatory Element Evolution Illustrated for the Senescence-Associated Cysteine Protease Gene SAG12 of Plants

E Vatov, U Ludewig, U Zentgraf - Plants, 2021 - mdpi.com
Gene regulation networks precisely orchestrate the expression of genes that are closely
associated with defined physiological and developmental processes such as leaf …

Archaea: the first domain of diversified life

G Caetano-Anollés, A Nasir, K Zhou… - …, 2014 - Wiley Online Library
The study of the origin of diversified life has been plagued by technical and conceptual
difficulties, controversy, and apriorism. It is now popularly accepted that the universal tree of …

Whence genes in pieces: reconstruction of the exon–intron gene structures of the last eukaryotic common ancestor and other ancestral eukaryotes

EV Koonin, M Csuros, IB Rogozin - Wiley Interdisciplinary …, 2013 - Wiley Online Library
In eukaryotes, protein‐coding sequences are interrupted by non‐coding sequences known
as introns. During mRNA maturation, introns are excised by the spliceosome and the coding …