Mitochondria ROS and mitophagy in acute kidney injury

L Su, J Zhang, H Gomez, JA Kellum, Z Peng - Autophagy, 2023 - Taylor & Francis
Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged
mitochondria and the production of reactive oxygen species (ROS). The relationship …

Metal-based photosensitizers as inducers of regulated cell death mechanisms

Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

“Electron transport chain interference” strategy of amplified mild-photothermal therapy and defect-engineered multi-enzymatic activities for synergistic tumor …

S Dong, Y Dong, Z Zhao, J Liu, S Liu… - Journal of the …, 2023 - ACS Publications
Arming activatable mild-photothermal therapy (PTT) with the property of relieving tumor
thermotolerance holds great promise for overcoming traditional mild PTT limitations such as …

Autophagy mediates an amplification loop during ferroptosis

S Lee, N Hwang, BG Seok, S Lee, SJ Lee… - Cell Death & …, 2023 - nature.com
Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …

Programmed cell death tunes tumor immunity

J Liu, M Hong, Y Li, D Chen, Y Wu, Y Hu - Frontiers in immunology, 2022 - frontiersin.org
The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

[HTML][HTML] Forsythoside a mitigates alzheimer's-like pathology by inhibiting ferroptosis-mediated neuroinflammation via Nrf2/GPX4 axis activation

C Wang, S Chen, H Guo, H Jiang, H Liu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Ferroptosis and neuroinflammation play crucial roles in Alzheimer's disease (AD)
pathophysiology. Forsythoside A (FA), the main constituent of Forsythia suspensa (Thunb.) …

Ferroptosis mechanisms involved in neurodegenerative diseases

CO Reichert, FA de Freitas, J Sampaio-Silva… - International journal of …, 2020 - mdpi.com
Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …

Autophagy: Regulator of cell death

SZ Liu, SJ Yao, H Yang, SJ Liu, YJ Wang - Cell death & disease, 2023 - nature.com
Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
Acute kidney injury (AKI) is a major public health problem with high incidence and mortality.
As a form of programmed cell death (PCD), ferroptosis could be considered as a process of …

Fighting age-related orthopedic diseases: focusing on ferroptosis

Q Ru, Y Li, W Xie, Y Ding, L Chen, G Xu, Y Wu… - Bone research, 2023 - nature.com
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation
and lipid peroxidation. It is closely related to multiple biological processes, including iron …