Asthma | From Bronchoconstriction to Airways Inflammation and Remodeling | American
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Shortly after its introduction into therapy, aspirin was implicated as the cause of a violent
broncho-spasm. Adverse reactions to aspirin and other non-steroidal anti-inflammatory …

Phosphoinositide 3-kinase (PI3K) is thought to contribute to the pathogenesis of asthma by
effecting the recruitment, activation, and apoptosis of inflammatory cells. We examined the …

The reaction of nitric oxide (NO) and superoxide anions (O2−) in the airway results in the
formation of peroxynitrite, a highly reactive oxidant species. Peroxynitrite reacts with tyrosine …

Background Cysteinyl leukotrienes are capable of inducing chemotaxis of eosinophils in
vitro and within the airways of animals and humans in vivo. Objective We hypothesized that …

Intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-
1) are members of the immunoglobulin superfamily adhesion molecules on vascular …

1. The effects of the non‐selective phosphodiesterase (PDE) inhibitor theophylline and the
selective PDE4 inhibitor rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of …

Recruitment and activation of eosinophils into the airways of asthma patients is suggested to
be a contributing causative agent in the histopathologies and lung dysfunction that are …

We studied the effects of the 5-lipoxygenase inhibition and sulfidopeptidyl leukotriene
receptor antagonism on lumenal chemotaxis of eosinophils in 124 guinea pig tracheal …

Isolated airway smooth muscle has been extensively investigated since 1840 to understand
the pharmacology of airway diseases. There has often been poor predictability from murine …