Metal compounds against neglected tropical diseases

YC Ong, S Roy, PC Andrews, G Gasser - Chemical reviews, 2018 - ACS Publications
Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

An update on natural antileishmanial treatment options from plants, fungi and algae

WS Koko, IS Al Nasr, TA Khan… - Chemistry & …, 2022 - Wiley Online Library
Efficient drugs for the treatment of leishmaniasis, which is classified as a neglected tropical
disease, are sought for. This review covers potential drug candidates from natural plant …

The Anti-Leishmania amazonensis and Anti-Leishmania chagasi Action of Copper(II) and Silver(I) 1,10-Phenanthroline-5,6-dione Coordination Compounds

SSC Oliveira, VS Santos, M Devereux, M McCann… - Pathogens, 2023 - mdpi.com
Leishmaniasis is a neglected disease caused by protozoa belonging to the Leishmania
genus. Notably, the search for new, promising and potent anti-Leishmania compounds …

Molecular-level strategic goals and repressors in Leishmaniasis–Integrated data to accelerate target-based heterocyclic scaffolds

M Abirami, BK Kumar, S Dey, S Johri… - European Journal of …, 2023 - Elsevier
Leishmaniasis is a complex of neglected tropical diseases caused by various species of
leishmanial parasites that primarily affect the world's poorest people. A limited number of …

A “Golden Age” for the discovery of new antileishmanial agents: current status of leishmanicidal gold complexes and prospective targets beyond the trypanothione …

LB Rosa, RL Aires, LS Oliveira, JV Fontes… - …, 2021 - Wiley Online Library
Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious
public health issue. The current therapeutic options have several disadvantages that make …

Metallodrugs for the treatment of trypanosomatid diseases: Recent advances and new insights

M Navarro, RMS Justo, GYS Delgado… - Current …, 2021 - benthamdirect.com
Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

Evaluation of scolicidal potential of salicylate coated zinc nanoparticles against Echinococcus granulosus protoscoleces

K Cheraghipour, M Azarhazine, M Zivdari… - Experimental …, 2023 - Elsevier
Echinococcosis is a zoonotic disease caused by larval stages of the Echinococcus genus
(metastasis). In this study, salicylate-coated Zinc oxide nanoparticles (SA-ZnO-NPs) were …

DNA topoisomerases in the unicellular protozoan parasites: Unwinding the mystery

S Lamba, A Roy - Biochemical Pharmacology, 2022 - Elsevier
DNA topoisomerases are a group of enzymes present ubiquitously in all organisms from
unicellular protozoan parasites to humans. These enzymes control the topological problems …

Antileishmanial and Anti‐Chikungunya Activity of Cu (I)‐N‐Heterocyclic Carbenes

JV Fontes, IA Santos, LB Rosa, RLA Lima… - …, 2022 - Wiley Online Library
Neglected tropical diseases such as Leishmaniasis and Chikungunya fever are worldwide
public health challenges mainly affecting tropical and subtropical countries. One cationic [Cu …

Synthesis, characterization and antileishmanial activity of copper (II) and zinc (II) complexes with diamine ligands

CASR Condé, MV De Almeida, GS Da Silva… - Transition Metal …, 2022 - Springer
A new set of copper-and zinc-diamine (N-alkylated (L1) and N, N'-dialkylated (L2))
complexes,[Cu (L1) 2 (NO3) 2](1),[Cu (L1) 2 (Cl) 2]. 5H2O (2),[Cu (L2) 2 (NO3) 2](3),[Cu (L2) …