This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

During exercise the cardiovascular system has to warrant substrate supply to working
muscle. The main function of red blood cells in exercise is the transport of O2 from the lungs …

Extracellular ATP (eATP) is an ancient 'danger signal'used by eukaryotes to detect cellular
damage. In mice and humans, the release of eATP during inflammation or injury stimulates …

Apoptotic cells release 'find-me'signals at the earliest stages of death to recruit phagocytes.
The nucleotides ATP and UTP represent one class of find-me signals, but their mechanism …

Stimulation of almost all mammalian cell types leads to the release of cellular ATP and
autocrine feedback through a diverse array of purinergic receptors. Depending on the types …

Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Abstract The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered
the cell's primary energy currency. Importantly, a novel role for ATP as an extracellular …

Extracellular nucleotides and nucleosides promote a vast range of physiological responses,
via activation of cell surface purinergic receptors. Virtually all tissues and cell types exhibit …

The NLRP3 inflammasome is a protein complex involved in IL-1β and IL-18 processing that
senses pathogen-and danger-associated molecular patterns (PAMPs and DAMPs). One …

Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …