Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

At the surface of many cells is a compendium of glycoconjugates that form an interface
between the cell and its surroundings; the glycocalyx. The glycocalyx serves several …

Abstract Glutamine fructose-6-phosphate amidotransferase (GFAT) is the key enzyme in the
hexosamine pathway (HP) that produces uridine 5′-diphospho-N-acetyl-d-glucosamine …

As an essential enzyme in the uridine diphosphate (UDP)‐GlcNAc biosynthesis pathway,
the significant role of N‐acetylglucosamine phosphate mutase (AGM) remains unknown in …

N-Acetylglucosamine (GlcNAc), a fundamental amino sugar moiety, is essential for protein
glycosylation, glycolipid, GPI-anchor protein, and cell wall components. Uridine diphosphate …

Sialic acids are part of the outermost component of the glycocalyx of all vertebrates; as such,
they are fundamental markers in physiological and pathological processes. In this study, we …

Bio-orthogonal chemistries have revolutionized many fields. For example, metabolic
chemical reporters (MCRs) of glycosylation are analogues of monosaccharides that contain …

Abstract Glutamine: fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting
enzyme of the hexosamine biosynthetic pathway (HBP), an important route for de novo …

Glycans play essential roles in a range of cellular processes and have been shown to
contribute to various pathologies. The diversity and dynamic nature of glycan structures and …

Sialic acids are part of the outermost component of the glycocalyx of all vertebrates. As such,
they are fundamental markers in physiological and pathological processes. The “master …