This review focuses on recently developed alginate injectable hydrogels and alginate
composites for applications in bone tissue regeneration, and it evaluates the alternatives to …

Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …

Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

Summary Whole-genome-sequencing (WGS) of human tumors has revealed distinct
mutation patterns that hint at the causative origins of cancer. We examined mutational …

We present an extensive assessment of mutation burden through sequencing analysis of>
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …

Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …

Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …

The rate of skin aging, or that of tissue in general, is determined by a variable predominance
of tissue degeneration over tissue regeneration. This review discusses the role of oxidative …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …