Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

A major challenge in tuberculosis control is the diagnosis and treatment of latent
tuberculosis infection. Until recently, there were no alternatives to the tuberculin skin test …

Objectives To evaluate the effectiveness of available rapid diagnostic tests to identify
tuberculosis (TB) infection. Data sources Electronic databases were searched from 1975 to …

Mycobacterium tuberculosis is one of the most ubiquitous pathogens in the world: estimates
are that roughly one third of the world's population is infected with the bacillus, and it is …

Tests based on tuberculin purified protein derivative (PPD) cannot distinguish between
tuberculosis infection, Mycobacterium bovis BCG vaccination, or exposure to environmental …

ContextIdentifying persons with latent tuberculosis infection (LTBI) is crucial to the goal of TB
elimination. A whole-blood interferon γ (IFN-γ) assay, the QuantiFERON-TB test, is a …

Human T cell responses to ESAT-6 and eight synthetic overlapping peptides were
investigated in tuberculosis (TB) patients and control subjects from regions of high and low …

The wide spectrum of clinical outcomes following infection with Mycobacterium tuberculosis
is largely determined by the host immune response; therefore, we studied several clinically …

Several genes coding for different cytokines may affect host susceptibility to tuberculosis.
This study investigates the relationship of the single base change polymorphic variants …