Malignant brain tumors constitute nearly one-third of cancer diagnoses in children and have
recently surpassed hematologic malignancies as the most lethal neoplasm in the pediatric …

Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of
pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall …

Herpes simplex virus (HSV) can be genetically altered to acquire oncolytic properties so that
oncolytic HSV (oHSV) preferentially replicates in and kills cancer cells, while sparing normal …

Medulloblastoma (MB) is a major pediatric malignant brain tumor that arises in the
cerebellum. MB tumors exhibit highly heterogeneous driven by diverse genetic alterations …

Introduction To overcome the challenge of treating malignant brain tumors, oncolytic viruses
(OVs) represent an innovative therapeutic approach, featuring unique mechanisms of action …

Over the past decade, remarkable progress has been made towards elucidating the origin
and genomic landscape of childhood high-grade brain tumours. It has become evident that …

Since the discovery that cGAS/STING recognizes endogenous DNA released from dying
cancer cells and induces type I interferon and antitumor T cell responses, efforts to …

Simple Summary Oncolytic virotherapy (OVT) is a promising approach in cancer
immunotherapy. Oncolytic viruses (OVs) could be applied in cancer immunotherapy without …

OBJECTIVE The diagnosis of glioma remains disheartening in the clinical realm. While a
multitude of studies and trials have shown promise, improvements in overall survival have …

Glioblastoma (GBM) is a lethal primary malignant brain tumor with no current effective
treatments. The recent emergence of immuno-virotherapy and FDA approval of T-VEC have …