Early studies of transcriptional regulation focused on individual gene promoters defined
specific transcription factors as central agents of genetic control. However, recent genome …

The cell-division cycle (CDC) is driven by cyclin-dependent kinases (CDKs). Mathematical
models based on molecular networks, as revealed by molecular and genetic studies, have …

Cells have evolved oscillators with different frequencies to coordinate periodic processes.
Here we studied the interaction of two oscillators, the cell division cycle (CDC) and the yeast …

Adaptive survival requires the coordination of nutrient availability with expenditure of cellular
resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes …

Britton Chance, electronics expert when a teenager, became an enthusiastic student of
biological oscillations, passing on this enthusiasm to many students and colleagues …

Abstract We review Don Gilbert's pioneering seminal contributions that both detailed the
mathematical principles and the experimental demonstration of several of the key dynamic …

It is important to understand the structure and function of Baker's yeast as it serves as an
excellent model, not only for many other fungi but also for almost all eukaryotic cell systems …

The dynamic complexity of the living state as evident on viewing cells microscopically defies
immediate comprehension. Experiment and theory now allows us to approach some of the …

Metabolic oscillations in budding yeast percolate throughout cellular physiology. The
transcriptome oscillates between expression of genes encoding for biosynthesis and growth …

When yeast cultures are grown to a high cell density they tend to show collective metabolic
dynam-30 ics, alternating between phases of high oxygen consumption (HOC) and low …