Primary immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder
characterized by decreased platelet counts and an increased risk of bleeding. Multiple …

Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell
response, notably supported by splenic T follicular helper cells, that stimulates the …

After being absorbed, drugs distribute in the body in part to reach target tissues, in part to be
disposed in tissues where they do not exert clinically-relevant effects. Therapeutically …

Immune thrombocytopenia (ITP) is the most common acquired thrombocytopenia after
chemotherapy-induced thrombocytopenia. Existing guidelines describe the management …

Splenectomy is an effective therapy for steroid-refractory or dependent immune
thrombocytopenia (ITP). With the advent of medical alternatives such as rituximab and …

Pre-existing serum antibodies play an important role in vaccine-mediated protection against
infection but the underlying mechanisms of immune memory are unclear. Clinical studies …

The mechanisms underlying the maintenance of long-lasting humoral immunity are not well
understood. Studies in mice indicate that plasma cells (PCs) can survive up to a lifetime …

Objective To compare response to rituximab (RTX) between adult patients positive for
myelin oligodendrocyte glycoprotein (MOG) and aquaporin‐4 (AQP4) antibodies. Methods …

Ectopic lymphoid neogenesis often occurs in the target tissues of patients with chronic
rheumatic autoimmune diseases such as rheumatoid arthritis, Sjögren syndrome and other …

CD20 is a B cell-specific membrane protein and represents an attractive target for
therapeutic antibodies. Despite widespread usage of anti-CD20 antibodies for B cell …