The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Our ever‐increasing understanding of biological systems is providing a range of exciting
novel biological targets, whose modulation may enable novel therapeutic options for many …

The estrogen receptor (ER) is a validated target for the treatment of estrogen receptor-
positive (ER+) breast cancer. Here, we describe the design, synthesis, and extensive …

Re-activation and clonal expansion of tumor-specific antigen (TSA)-reactive T cells are
critical to the success of checkpoint blockade and adoptive transfer of tumor-infiltrating …

The immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide, all
approved for the treatment of multiple myeloma, induce targeted ubiquitination and …

Visualizing and manipulating the behavior of proteins is crucial to understanding the
physiology of the cell. Methods of biorthogonal protein labeling are important tools to attain …

Inducing biomolecular interactions with synthetic molecules to impact biological function is a
concept of enormous appeal. Recent years have seen a resurgence of interest in designing …

The visualization of glycosylation states of specific proteins in vivo is of great importance for
uncovering their roles in disease development. However, the ubiquity of glycosylation …

Molecular conjugation refers to methods used in biomedicine, advanced materials and
nanotechnology to link two partners—from small molecules to large and sometimes …

Mutations to RAS proteins (H-, N-, and K-RAS) are among the most common oncogenic
drivers, and tumors harboring these lesions are some of the most difficult to treat. Although …