Mammalian lipin phosphatidic acid phosphatases in lipid synthesis and beyond: metabolic and inflammatory disorders

K Reue, H Wang - Journal of lipid research, 2019 - ASBMB
The regulation of cellular lipid storage and membrane lipid composition plays a critical role
in metabolic homeostasis, and dysregulation may contribute to disorders such as obesity …

Regulation of signaling and metabolism by lipin-mediated phosphatidic acid phosphohydrolase activity

AJ Lutkewitte, BN Finck - Biomolecules, 2020 - mdpi.com
Phosphatidic acid (PA) is a glycerophospholipid intermediate in the triglyceride synthesis
pathway that has incredibly important structural functions as a component of cell membranes …

[HTML][HTML] Phosphatidate phosphatase Lipin1 involves in diabetic encephalopathy pathogenesis via regulating synaptic mitochondrial dynamics

X Han, S Huang, Z Zhuang, X Zhang, M Xie, N Lou… - Redox Biology, 2024 - Elsevier
Diabetic encephalopathy (DE) is a common central nervous system complication of diabetes
mellitus without effective therapy currently. Recent studies have highlighted synaptic …

Supplemental Clostridium butyricum modulates skeletal muscle development and meat quality by shaping the gut microbiota of lambs

L Dou, C Liu, X Chen, Z Yang, G Hu, M Zhang, L Sun… - Meat Science, 2023 - Elsevier
This study evaluated the contributions of Clostridium butyricum on skeletal muscle
development, gastrointestinal flora and meat quality of lambs. Eighteen Dorper (♂)× Small …

[HTML][HTML] Low lysophosphatidylcholine induces skeletal muscle myopathy that is aggravated by high-fat diet feeding

PJ Ferrara, ARP Verkerke, JA Maschek… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Obesity alters skeletal muscle lipidome and promotes myopathy, but it is unknown whether
aberrant muscle lipidome contributes to the reduction in skeletal muscle contractile force …

Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model

AD Prabakaran, K McFarland, K Miz… - The Journal of …, 2024 - Am Soc Clin Investig
Sarcopenia burdens the older population through loss of muscle energy and mass, yet
treatments to functionally rescue both parameters are lacking. The glucocorticoid …

Adipocyte lipin 1 expression associates with human metabolic health and regulates systemic metabolism in mice

A LaPoint, JM Singer, D Ferguson, TM Shew… - The Journal of Clinical …, 2024 - jci.org
Dysfunctional adipose tissue is believed to promote the development of hepatic steatosis
and systemic insulin resistance, but many of the mechanisms involved are still unclear. Lipin …

Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone‐responsive myopathy

T Rashid, I Nemazanyy, C Paolini, T Tatsuta… - The EMBO …, 2019 - embopress.org
As a consequence of impaired glucose or fatty acid metabolism, bioenergetic stress in
skeletal muscles may trigger myopathy and rhabdomyolysis. Genetic mutations causing loss …

Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy

A Jama, AA Alshudukhi, S Burke, L Dong… - Journal of Translational …, 2024 - Springer
Background Duchenne muscular dystrophy (DMD) is a progressive and devastating muscle
disease, resulting from the absence of dystrophin. This leads to cell membrane instability …

[HTML][HTML] SOD2 in skeletal muscle: New insights from an inducible deletion model

A Zhuang, C Yang, Y Liu, Y Tan, ST Bond, S Walker… - Redox Biology, 2021 - Elsevier
Metabolic conditions such as obesity, insulin resistance and glucose intolerance are
frequently associated with impairments in skeletal muscle function and metabolism. This is …