RNA-guided RNA modifications: biogenesis, functions, and applications
Conspectus Post-transcriptional modifications are ubiquitous in both protein-coding and
noncoding RNAs (ncRNAs), playing crucial functional roles in diverse biological processes …
noncoding RNAs (ncRNAs), playing crucial functional roles in diverse biological processes …
Quantification and mapping of RNA modifications
J Xiong, J Wu, Y Liu, YJ Feng, BF Yuan - TrAC Trends in Analytical …, 2024 - Elsevier
In addition to the four canonical nucleobases, RNA molecules undergo various chemical
modifications. To date, more than 170 structurally diverse RNA modifications have been …
modifications. To date, more than 170 structurally diverse RNA modifications have been …
2′-O-methylation at internal sites on mRNA promotes mRNA stability
O-methylation (Nm) is a prominent RNA modification well known in noncoding RNAs and
more recently also found at many mRNA internal sites. However, their function and base …
more recently also found at many mRNA internal sites. However, their function and base …
Accurate Quantification of Ten Methylated Purine Nucleosides by Highly Sensitive and Stable Isotope-Diluted UHPLC–MS/MS
L Zhang, W Zhang, H Wang - Analytical Chemistry, 2024 - ACS Publications
The dynamic landscape of cellular nucleotides/nucleosides associated with RNA
metabolism, particularly in diseases like cancer, has spurred intensive interest. Here, we …
metabolism, particularly in diseases like cancer, has spurred intensive interest. Here, we …
SNORD3A Regulates STING Transcription to Promote Ferroptosis in Acute Kidney Injury
H Zhu, J Wang, J Miao, M Shen, H Wang… - Advanced …, 2024 - Wiley Online Library
Acute kidney injury (AKI) signifies a sudden and prolonged decline in kidney function
characterized by tubular cell death and interstitial inflammation. Small nucleolar RNAs …
characterized by tubular cell death and interstitial inflammation. Small nucleolar RNAs …
Nmix: a hybrid deep learning model for precise prediction of 2'-O-methylation sites based on multi-feature fusion and ensemble learning
Abstract RNA 2'-O-methylation (Nm) is a crucial post-transcriptional modification with
significant biological implications. However, experimental identification of Nm sites is …
significant biological implications. However, experimental identification of Nm sites is …
Untacking small RNA profiling and RNA fragment footprinting: Approaches and challenges in library construction
Small RNAs (sRNAs) with sizes ranging from 15 to 50 nucleotides (nt) are critical regulators
of gene expression control. Prior studies have shown that sRNAs are involved in a broad …
of gene expression control. Prior studies have shown that sRNAs are involved in a broad …
[HTML][HTML] RNA epigenetics in pulmonary diseases: Insights into methylation modification of lncRNAs in lung cancer
J Jiang, M Duan, Z Wang, Y Lai, C Zhang… - Biomedicine & …, 2024 - Elsevier
Long non-coding RNAs (lncRNAs) are pivotal controllers of gene expression through
epigenetic mechanisms, Methylation, a prominent area of study in epigenetics, significantly …
epigenetic mechanisms, Methylation, a prominent area of study in epigenetics, significantly …
Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway
The spreading of cancer cells from the primary tumor site to other parts of the body, known
as metastasis, is the leading cause of cancer recurrence and mortality in patients with triple …
as metastasis, is the leading cause of cancer recurrence and mortality in patients with triple …
Advances in mapping analysis of ribonucleic acid modifications through sequencing
J Xiong, T Feng, BF Yuan - Se pu= Chinese Journal of …, 2024 - europepmc.org
迄今为止, 已在核糖核酸 (RNA) 中发现了 170 多种不同的化学修饰, 这些修饰分布在各种类型的
RNA 中, 包括信使 RNA (mRNA), 核糖体 RNA (rRNA), 转运 RNA (tRNA) 和小核 RNA (snRNA) …
RNA 中, 包括信使 RNA (mRNA), 核糖体 RNA (rRNA), 转运 RNA (tRNA) 和小核 RNA (snRNA) …