ABSTRACT Introduction: Telomere biology disorders (TBDs) encompass a group of
illnesses caused by germline mutations in genes regulating telomere maintenance, resulting …

Epidemiological studies have principally relied on measurements of telomere length (TL) in
leucocytes, which reflects TL in other somatic cells. Leucocyte TL (LTL) displays vast …

Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …

INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …

Studies of rare and common illnesses have led to remarkable progress in the understanding
of the role of telomeres (nucleoprotein complexes at chromosome ends essential for …

The medical, public health, and scientific communities are grappling with monumental
imperatives to contain COVID‐19, develop effective vaccines, identify efficacious treatments …

Individuals with short telomeres should be at increased risk for cancer, since short telomeres
lead to genomic instability–a hallmark of cancer. However, individuals with long telomeres …

The human brain is the outcome of innumerable evolutionary processes; the systems
genetics of psychiatric disorders could bear their signatures. On this basis, we analyzed five …

An ongoing debate in demography has focused on whether the human lifespan has a
maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres …

Telomeres are protective structures at the ends of linear chromosomes. Shortened telomere
lengths (TL) are an indicator of premature biological aging and have been associated with a …