The role of copper homeostasis in brain disease

Y An, S Li, X Huang, X Chen, H Shan… - International journal of …, 2022 - mdpi.com
In the human body, copper is an important trace element and is a cofactor for several
important enzymes involved in energy production, iron metabolism, neuropeptide activation …

Ribosomal proteins: functions beyond the ribosome

X Zhou, WJ Liao, JM Liao, P Liao… - Journal of molecular cell …, 2015 - academic.oup.com
Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …

Uncovering the assembly pathway of human ribosomes and its emerging links to disease

KE Bohnsack, MT Bohnsack - The EMBO journal, 2019 - embopress.org
The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

Specialized ribosomes: a new frontier in gene regulation and organismal biology

S Xue, M Barna - Nature reviews Molecular cell biology, 2012 - nature.com
Historically, the ribosome has been viewed as a complex ribozyme with constitutive rather
than intrinsic regulatory capacity in mRNA translation. However, emerging studies reveal …

Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions

N Sen, BD Paul, MM Gadalla, AK Mustafa, T Sen, R Xu… - Molecular cell, 2012 - cell.com
Nuclear factor κB (NF-κB) is an antiapoptotic transcription factor. We show that the
antiapoptotic actions of NF-κB are mediated by hydrogen sulfide (H 2 S) synthesized by …

Shared principles in NF-κB signaling

MS Hayden, S Ghosh - Cell, 2008 - cell.com
The transcription factor NF-κB has served as a standard for inducible transcription factors for
more than 20 years. The numerous stimuli that activate NF-κB, and the large number of …

Regulation and function of NF-κB transcription factors in the immune system

S Vallabhapurapu, M Karin - Annual review of immunology, 2009 - annualreviews.org
The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

Y Wang, C Wu, Y Du, Z Li, M Li, P Hou, Z Shen, S Chu… - Molecular cancer, 2022 - Springer
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …

New insights into CDK regulators: novel opportunities for cancer therapy

M Bury, B Le Calvé, G Ferbeyre, V Blank, F Lessard - Trends in cell biology, 2021 - cell.com
Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the
transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK …

NF-κB in renal inflammation

AB Sanz, MD Sanchez-Niño, AM Ramos… - Journal of the …, 2010 - journals.lww.com
The NF-κB family of transcription factors regulates the induction and resolution of
inflammation. Two main pathways, classical and alternative, control the nuclear …