The ABCs of rhinoviruses, wheezing, and asthma

JE Gern - Journal of virology, 2010 - Am Soc Microbiol
Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years
ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role …

Epithelial cells and airway diseases

D Proud, R Leigh - Immunological reviews, 2011 - Wiley Online Library
The airway epithelial cell is the initial cell type impacted both by inhaled environmental
factors, such as pathogens, allergens, and pollutants, and inhaled medications for airway …

Quercetin inhibits rhinovirus replication in vitro and in vivo

S Ganesan, AN Faris, AT Comstock, Q Wang, S Nanua… - Antiviral research, 2012 - Elsevier
Rhinovirus (RV), which is responsible for the majority of common colds, also causes
exacerbations in patients with asthma and chronic obstructive pulmonary disease. So far …

Rhinovirus induces an anabolic reprogramming in host cell metabolism essential for viral replication

GA Gualdoni, KA Mayer, AM Kapsch… - Proceedings of the …, 2018 - National Acad Sciences
Rhinoviruses (RVs) are responsible for the majority of upper airway infections; despite their
high prevalence and the resulting economic burden, effective treatment is lacking. We report …

Picornaviruses

TJ Tuthill, E Groppelli, JM Hogle… - Cell Entry by Non …, 2010 - Springer
The picornavirus family consists of a large number of small RNA viruses, many of which are
significant pathogens of humans and livestock. They are amongst the simplest of vertebrate …

Kinases as novel therapeutic targets in asthma and chronic obstructive pulmonary disease

PJ Barnes, C Page - Pharmacological Reviews, 2016 - Elsevier
Multiple kinases play a critical role in orchestrating the chronic inflammation and structural
changes in the respiratory tract of patients with asthma and chronic obstructive pulmonary …

[HTML][HTML] Syk and pTyr'd: Signaling through the B cell antigen receptor

RL Geahlen - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2009 - Elsevier
The B cell receptor (BCR) transduces antigen binding into alterations in the activity of
intracellular signaling pathways through its ability to recruit and activate the cytoplasmic …

Porcine epidemic diarrhea virus ORF3 protein causes endoplasmic reticulum stress to facilitate autophagy

D Zou, J Xu, X Duan, X Xu, P Li, L Cheng, L Zheng… - Veterinary …, 2019 - Elsevier
Porcine epidemic diarrhea virus (PEDV), the causative agent of PED, is an enveloped,
positive-stranded RNA virus in the genus Alphacoronavirus, family Coronaviridae, order …

Rhinoviruses and their receptors: implications for allergic disease

YA Bochkov, JE Gern - Current allergy and asthma reports, 2016 - Springer
Human rhinoviruses (RVs) are picornaviruses that can cause a variety of illnesses including
the common cold, lower respiratory tract illnesses such as bronchitis and pneumonia, and …

Rhinoviruses, allergic inflammation, and asthma

ML Gavala, PJ Bertics, JE Gern - Immunological reviews, 2011 - Wiley Online Library
Viral infections affect wheezing and asthma in children and adults of all ages. In infancy,
wheezing illnesses are usually viral in origin, and children with more severe wheezing …