Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …

Genetically diverse mouse populations are powerful tools for characterizing the regulation of
the proteome and its relationship to whole-organism phenotypes. We used mass …

Gene transcription profiles across tissues are largely defined by the activity of regulatory
elements, most of which correspond to regions of accessible chromatin. Regulatory element …

Cultured pluripotent cells accumulate detrimental chromatin alterations, including DNA
methylation changes at imprinted genes known as loss of imprinting (LOI). Although the …

Gene expression is known to be affected by interactions between local genetic variation and
DNA accessibility, with the latter organized into three-dimensional chromatin structures …

Influenza A virus (IAV) causes an acute respiratory disease, and is estimated to affect 50
million people annually in the United States alone. Among infected individuals, severity of …

Les cellules endothéliales (CE) et les cellules hématopoïétiques dérivées des cellules
souches pluripotentes humaines (CSPh) sont un outil prometteur pour l'ingénierie tissulaire …