[HTML][HTML] Nasopharyngeal carcinoma ecology theory: Cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem

W Luo - Theranostics, 2023 - ncbi.nlm.nih.gov
Nasopharyngeal carcinoma (NPC) is a particular entity of head neck cancer that is generally
regarded as a genetic disease with diverse intertumor and intratumor heterogeneity. This …

Improving cancer treatments via dynamical biophysical models

M Kuznetsov, J Clairambault, V Volpert - Physics of life reviews, 2021 - Elsevier
Despite significant advances in oncological research, cancer nowadays remains one of the
main causes of mortality and morbidity worldwide. New treatment techniques, as a rule …

A method for in silico exploration of potential glioblastoma multiforme attractors using single-cell RNA sequencing

MG Vieira Junior, AM de Almeida Côrtes… - Scientific Reports, 2024 - nature.com
We presented a method to find potential cancer attractors using single-cell RNA sequencing
(scRNA-seq) data. We tested our method in a Glioblastoma Multiforme (GBM) dataset, an …

Unveiling the Dynamics behind Glioblastoma Multiforme Single-Cell Data Heterogeneity

MGV Junior, AMA Côrtes, FRG Carneiro… - International Journal of …, 2024 - mdpi.com
Glioblastoma Multiforme is a brain tumor distinguished by its aggressiveness. We suggested
that this aggressiveness leads single-cell RNA-sequence data (scRNA-seq) to span a …

Mathematical modelling of cancer growth and drug treatments: taking into account cell population heterogeneity and plasticity

J Clairambault - 2023 European Control Conference (ECC), 2023 - ieeexplore.ieee.org
Mathematical models of cancer growth and evolution of cancer cell characteristics, aka traits
or phenotypes, together with optimisation and optimal control methods to contain them, in …

Thinking in 3 dimensions: philosophies of the microenvironment in organoids and organs-on-chip

S Caianiello, M Bertolaso, G Militello - History and Philosophy of the Life …, 2023 - Springer
Organoids and organs-on-a-chip are currently the two major families of 3D advanced
organotypic in vitro culture systems, aimed at reconstituting miniaturized models of …

From Metaphysics to Methods?: Pluralism in Cancer Research

K Valde - Acta Analytica, 2024 - Springer
There is a growing recognition among many scientists and philosophers that metaphysical
presuppositions guide scientific research. These ontological claims, in turn, prescribe a …

Everything in moderation or moderating everything? Nutrient balancing in the context of evolution and cancer metabolism

J Sholl - Biology & Philosophy, 2022 - Springer
While philosophers of science have marginally discussed concepts such as
'nutrient','naturalness','food', or the 'molecularization'of nutrition, they have yet to seriously …

[图书][B] Explaining Disease: Philosophical Reflections on Medical Research and Clinical Practice

R Campaner - 2022 - Springer
The main purpose of the series is to provide a publication platform to young researchers
working in Europe, who will thus be encouraged to publish in English and make their work …

Complexity and Integration

R Campaner - … : Philosophical Reflections on Medical Research and …, 2022 - Springer
Complex diseases can be understood as brought about by wide range of heterogeneous
factors, which act probabilistically, interact with each other, and are extremely sensitive to …