Antimicrobial multidrug resistance: clinical implications for infection management in critically ill patients

G Kalın, E Alp, A Chouaikhi, C Roger - Microorganisms, 2023 - mdpi.com
The increasing incidence of antimicrobial resistance (AMR) worldwide represents a serious
threat in the management of sepsis. Due to resistance to the most common antimicrobials …

The interventions and challenges of antimicrobial stewardship in the emergency department

J Ruiz-Ramos, L Escolà-Vergé, ÁE Monje-López… - Antibiotics, 2023 - mdpi.com
Over the last decades, we have witnessed a constant increase in infections caused by multi-
drug-resistant strains in emergency departments. Despite the demonstrated effectiveness of …

Antimicrobial susceptibility testing: An updated primer for clinicians in the era of antimicrobial resistance: Insights from the Society of Infectious Diseases Pharmacists

E Wenzler, M Maximos, TE Asempa… - … : The Journal of …, 2023 - Wiley Online Library
Antimicrobial susceptibility testing (AST) is a critical function of the clinical microbiology
laboratory and is essential for optimizing care of patients with infectious diseases …

Clinical impact of the accelerate PhenoTest® BC system on patients with gram-negative bacteremia and high risk of antimicrobial resistance: a prospective before …

T Brosh-Nissimov, A Tzur, D Grupel, A Cahan… - Annals of Clinical …, 2023 - Springer
Abstract Background The Accelerate PhenoTest® BC system (AXDX) is a novel assay for
rapid bacterial identification and antimicrobial susceptibility (AST). We report an evaluation …

Evaluation of the performance and clinical impact of a Rapid phenotypic susceptibility testing method directly from positive blood culture at a Pediatric Hospital

TT Truong, K Mongkolrattanothai, II Flores… - Journal of Clinical …, 2022 - Am Soc Microbiol
Bloodstream infection poses a significant medical emergency that necessitates timely
administration of appropriate antibiotics. Standard laboratory workup for antimicrobial …

Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach …

A Loiodice, S Bailly, S Ruckly, N Buetti, F Barbier… - Clinical Microbiology …, 2024 - Elsevier
Objectives Hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit
(ICU) are common life-threatening events. We aimed to investigate the association between …

Empirical antibiotic therapy for difficult-to-treat Gram-negative infections: when, how, and how long?

M Bassetti, A Vena, L Labate… - Current Opinion in …, 2022 - journals.lww.com
Novel agents should be used in line with antimicrobial stewardship principles, aimed at
reducing selective pressure for antimicrobial resistance. However, this does not mean that …

From bottle to bedside: Implementation considerations and antimicrobial stewardship considerations for bloodstream infection rapid diagnostic testing

JS Lapin, RD Smith, KM Hornback… - … : The Journal of …, 2023 - Wiley Online Library
Antimicrobial stewardship (AMS) programs have been quick to adopt novel molecular rapid
diagnostic technologies (mRDTs) for bloodstream infections (BSIs) to improve antimicrobial …

Comprehensive pathogen identification and antimicrobial resistance prediction from positive blood cultures using nanopore sequencing technology

PY Liu, HC Wu, YL Li, HW Cheng, CH Liou, FJ Chen… - Genome Medicine, 2024 - Springer
Background Blood cultures are essential for diagnosing bloodstream infections, but current
phenotypic tests for antimicrobial resistance (AMR) provide limited information. Oxford …

Evaluating the impact of rapid antimicrobial susceptibility testing for bloodstream infections: a review of actionability, antibiotic use and patient outcome metrics

SH MacVane, HP Dwivedi - Journal of Antimicrobial …, 2024 - academic.oup.com
Antimicrobial susceptibility testing (AST) is a core function of the clinical microbiology
laboratory and is critical to the management of patients with bloodstream infections (BSIs) to …