Liquid chromatography–tandem mass spectrometry (LC–MS/MS)-based proteomics is a
powerful technique for profiling proteomes of cells, tissues, and body fluids. Typical bottom …

Mesenchymal stem cells (MSCs) are multipotent cells with a substantial potential in human
regenerative medicine due to their ability to migrate to sites of injury, capability to suppress …

Single-cell transcriptomics (scRNA-seq) has revolutionized the understanding of the spatial
architecture of tissue structure and function. Advancing the" transcript-centric" view of scRNA …

Background Phosphorylation is the most frequent post-translational modification made to
proteins and may regulate protein activity as either a molecular digital switch or a rheostat …

Mass-spectrometry-based proteomics has evolved as the preferred method for the analysis
of complex proteomes. Undoubtedly, recent advances in mass spectrometry instrumentation …

The development of novel therapies against neurodegenerative disorders requires the
ability to detect their early, presymptomatic manifestations in order to enable treatment …

Phosphorylation is a form of protein posttranslational modification (PTM) that regulates many
biological processes. Whereas phosphoproteomics is a scientific discipline that identifies …

Phosphorylation is one of the quickest post-translational modifications that controls
downstream signaling pathways regulating processes like cell proliferation, survival, and …

Abstract Background: Oxford Nanopore Technologies Ltd (Oxford, UK) have recently
commercialized MinION, a small single-molecule nanopore sequencer, that offers the …

Recent advancements in mass spectrometry (MS) have revolutionized quantitative
proteomics, with multiplex isotope labeling emerging as a key strategy for enhancing …