The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action
S Karkare, TTH Chung, F Collin, LA Mitchenall… - Journal of Biological …, 2013 - ASBMB
Tuberculosis and other bacterial diseases represent a significant threat to human health.
The DNA topoisomerases are excellent targets for chemotherapy, and DNA gyrase in …
The DNA topoisomerases are excellent targets for chemotherapy, and DNA gyrase in …
The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo [j] phenanthridine-7, 12-diones against Mycobacterium tuberculosis
D Cappoen, E Torfs, T Meiresonne, P Claes… - European Journal of …, 2019 - Elsevier
Tuberculosis (TB) still has a major impact on public health. In order to efficiently eradicate
this life-threatening disease, the exploration of novel anti-TB drugs is of paramount …
this life-threatening disease, the exploration of novel anti-TB drugs is of paramount …
Chemotherapeutic strategies and targets against resistant TB
N Shakya, B Agrawal, R Kumar - … tuberculosis-new approaches …, 2012 - books.google.com
Chemotherapeutic cure for about 40,000 years old lethal disease–TB (Callaway, 2008), was
started mere~ 65 years ago, with the discovery of antibiotic-streptomycin. A few effective …
started mere~ 65 years ago, with the discovery of antibiotic-streptomycin. A few effective …
[PDF][PDF] Desenvolvimento da síntese de possíveis indutores da glicoproteína-P
AFP Nunes - 2012 - core.ac.uk
Neste trabalho foram sintetizados os compostos 7-metil-juglona e emodina, e respectivos
derivados, utilizando uma abordagem de reacção de Diels-Alder. Para a obtenção dos …
derivados, utilizando uma abordagem de reacção de Diels-Alder. Para a obtenção dos …