The last several years have seen an emergence of literature documenting the utility of
combination antimicrobial therapy, particularly in the salvage of refractory methicillin …

Since the last century, methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has
become a major global and public health concern not only in terms of morbidity and mortality …

Background Due to the intelligent survival strategy and self-preservation of methicillin-
resistant Staphylococcus aureus (MRSA), many antibiotics are ineffective in treating MRSA …

Introduction: Combination therapy with daptomycin plus ceftaroline to treat methicillin-
resistant Staphylococcus aureus bacteremia has been reported to reduce methicillin …

Introduction Daptomycin is a bactericidal lipopeptide antibiotic approved for the treatment of
systemic infections (ie skin and soft tissue infections, bloodstream infections, infective …

Infections due to methicillin-resistant Staphylococcus aureus bacteremia (MRSAB) seriously
threaten public health due to poor outcomes and high mortality. The objective of this study is …

Staphylococcus aureus remains an important human pathogen of concern, with mortality
rates surpassing 30% in the case of severe systemic infections. Distinguishing methicillin …

Introduction MRSA is associated with causing a variety of infections including skin and skin
structure infections, catheter and device-related (eg central venous catheter, prosthetic heart …

Almost all bactericidal drugs require bacterial replication and/or metabolic activity for their
killing activity. When these processes are inhibited by bacteriostatic antibiotics, bacterial …

Background The cyclic anionic lipopeptide daptomycin is used in the treatment of severe
infections caused by Gram-positive pathogens, including MRSA. Daptomycin resistance …