Counter-regulatory renin–angiotensin system in cardiovascular disease

M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

The angiotensin AT2 receptor: from a binding site to a novel therapeutic target

UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - Elsevier
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

Angiotensin II revisited: new roles in inflammation, immunology and aging

A Benigni, P Cassis, G Remuzzi - EMBO molecular medicine, 2010 - embopress.org
That the renin–angiotensin system (RAS) is involved in regulation of blood pressure,
vasoconstriction, sodium intake and potassium excretion is well established. Studies in the …

Inflammation and angiotensin II

Y Suzuki, M Ruiz-Ortega, O Lorenzo, M Ruperez… - The international journal …, 2003 - Elsevier
Angiotensin II (AngII), the major effector peptide of renin–angiotensin system (RAS), is now
recognized as a growth factor that regulates cell growth and fibrosis, besides being a …

Renin-angiotensin system and cardiovascular risk

RE Schmieder, KF Hilgers, MP Schlaich, BMW Schmidt - The Lancet, 2007 - thelancet.com
The renin-angiotensin system is a major regulatory system of cardiovascular and renal
function. Basic research has revealed exciting new aspects, which could lead to novel or …

Renin-angiotensin-aldosterone system and progression of renal disease

C Rüster, G Wolf - Journal of the American Society of Nephrology, 2006 - journals.lww.com
Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful
maneuvers to slow progression of renal disease. Angiotensin II (AngII) has emerged in the …

Possible cancer-causing capacity of COVID-19: Is SARS-CoV-2 an oncogenic agent?

K Jahankhani, F Ahangari, IM Adcock, E Mortaz - Biochimie, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown diverse life-
threatening effects, most of which are considered short-term. In addition to its short-term …

New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology

G Wolf - European journal of clinical investigation, 2004 - Wiley Online Library
Although debated for many years whether haemodynamic or structural changes are more
important in the development of diabetic nephropathy, it is now clear that these processes …

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin receptors: interpreters of pathophysiological angiotensinergic stimuli

SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - Elsevier
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

Endothelial dysfunction in COVID-19: a unifying mechanism and a potential therapeutic target

P Ambrosino, IL Calcaterra, M Mosella, R Formisano… - Biomedicines, 2022 - mdpi.com
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a
worldwide emergency, until the declaration of the pandemic in March 2020. SARS-CoV-2 …