Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved from a binding site with unknown function to a firmly established major effector within the …
A Benigni, P Cassis, G Remuzzi - EMBO molecular medicine, 2010 - embopress.org
That the renin–angiotensin system (RAS) is involved in regulation of blood pressure, vasoconstriction, sodium intake and potassium excretion is well established. Studies in the …
Y Suzuki, M Ruiz-Ortega, O Lorenzo, M Ruperez… - The international journal …, 2003 - Elsevier
Angiotensin II (AngII), the major effector peptide of renin–angiotensin system (RAS), is now recognized as a growth factor that regulates cell growth and fibrosis, besides being a …
The renin-angiotensin system is a major regulatory system of cardiovascular and renal function. Basic research has revealed exciting new aspects, which could lead to novel or …
C Rüster, G Wolf - Journal of the American Society of Nephrology, 2006 - journals.lww.com
Inhibition of the renin-angiotensin-aldosterone system (RAAS) is one of the most powerful maneuvers to slow progression of renal disease. Angiotensin II (AngII) has emerged in the …
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown diverse life- threatening effects, most of which are considered short-term. In addition to its short-term …
G Wolf - European journal of clinical investigation, 2004 - Wiley Online Library
Although debated for many years whether haemodynamic or structural changes are more important in the development of diabetic nephropathy, it is now clear that these processes …
SS Karnik, H Unal, JR Kemp, KC Tirupula… - Pharmacological …, 2015 - Elsevier
The renin angiotensin system (RAS) produced hormone peptides regulate many vital body functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a worldwide emergency, until the declaration of the pandemic in March 2020. SARS-CoV-2 …