MicroRNA as a potential therapeutic molecule in cancer

J Szczepanek, M Skorupa, A Tretyn - Cells, 2022 - mdpi.com
Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy

S Trino, D Lamorte, A Caivano, L De Luca, A Sgambato… - Leukemia, 2021 - nature.com
In the era of precision medicine, liquid biopsy is becoming increasingly important in
oncology. It consists in the isolation and analysis of tumor-derived biomarkers, including …

The progression of HMGB1-induced autophagy in cancer biology

T Xu, L Jiang, Z Wang - OncoTargets and therapy, 2018 - Taylor & Francis
Autophagy is an important process of cellular degradation and has been proven to
contribute to tumorigenesis. High-mobility group box 1 (HMGB1) is an abundant nonhistone …

Clinical and biological aspects of myeloid leukemia in Down syndrome

AC Boucher, KJ Caldwell, JD Crispino, JE Flerlage - Leukemia, 2021 - nature.com
Children with Down syndrome are at an elevated risk of leukemia, especially myeloid
leukemia (ML-DS). This malignancy is frequently preceded by transient abnormal …

Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade

Y Wang, Q Lin, C Song, R Ma, X Li - Cancer cell international, 2020 - Springer
Background The pathogenesis of multiple myeloma (MM) is not completely known.
Uncovering the potential mechanism of MM initiation and progression is essential for …

Dysregulation of miRNA in leukemia: exploiting miRNA expression profiles as biomarkers

L Anelli, A Zagaria, G Specchia, P Musto… - International Journal of …, 2021 - mdpi.com
Micro RNAs (miRNAs) are a class of small non-coding RNAs that have a crucial role in
cellular processes such as differentiation, proliferation, migration, and apoptosis. miRNAs …

LncRNA KCNQ1OT1 controls cell proliferation, differentiation and apoptosis by sponging miR-326 to regulate c-Myc expression in acute myeloid leukemia.

P Cheng, P Lu, J Guan, Y Zhou, L Zou, X Yi… - …, 2020 - search.ebscohost.com
Long noncoding RNAs (lncRNAs) have been reported to play essential roles in
development and treatment of acute myeloid leukemia (AML). However, the role of lncRNA …

Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p

H Liu, Y Wu, S Wang, J Jiang, C Zhang, Y Jiang… - Bmc Cancer, 2019 - Springer
Background We aimed to investigate the correlation of Circ-SMARCA5 with disease severity
and prognosis in multiple myeloma (MM), and its underlying mechanisms in regulating cell …

Exosomal telomerase transcripts reprogram the microRNA transcriptome profile of fibroblasts and partially contribute to CAF formation

D Likonen, M Pinchasi, E Beery, Z Sarsor… - Scientific Reports, 2022 - nature.com
It is now well accepted that cancer cells change their microenvironment from normal to tumor-
supportive state to provide sustained tumor growth, metastasis and drug resistance. These …

Exosomal MiRNAs in pediatric cancers

A Galardi, M Colletti, V Di Paolo, P Vitullo… - International Journal of …, 2019 - mdpi.com
MicroRNAs (miRNAs) have generated great attention in oncology as they play a
fundamental role in the regulation of gene expression and their aberrant expression is …