While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key
model system for neural stem cell biology and have provided key insights into the …

The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …

Initiation is the rate-limiting step in translation, and its dysregulation is vital for
carcinogenesis, including hematopoietic malignancy. Thus, discovery of novel translation …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

Microglia maintain homeostasis in the brain. However, with age, they become primed and
respond more strongly to inflammatory stimuli. We show here that microglia from aged mice …