Background & Aims The differentiation of stem cells to hepatocyte-like cells (HLC) offers the
perspective of unlimited supply of human hepatocytes. However, the degree of …

Stem cell-derived somatic cells represent an unlimited resource for basic and translational
science. Although promising, there are significant hurdles that must be overcome. Our focus …

A long-term goal of numerous research projects is to identify biomarkers for in vitro systems
predicting toxicity in vivo. Often, transcriptomics data are used to identify candidates for …

Histological alterations often constitute a fingerprint of toxicity and diseases. The extent to
which these alterations are cause or consequence of compromised organ function, and the …

Dear editor, It is well known that huge research networks have been initiated by the EU to
establish in vitro test systems for toxicity testing (Liebsch et al., 2011; Bolt, 2013; Krug et al …

Chronic exposure of the liver to hepatotoxic agents initiates an aberrant wound healing
response marked by proinflammatory, as well as fibrotic, changes, leading to compromised …

The organic cation transporter 1 (OCT1) is the dominant carrier of organic cationic drugs and
some positively charged endogenous compounds into hepatocytes. OCT1 has unique …

The epithelial-to-mesenchymal transition (EMT) is known to have a role in appropriate
embryonic development, the physiological response to injury and pathological events such …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is closely associated with tissue
remodeling. Epithelial-to-mesenchymal transition (EMT), a process of tissue remodeling, can …

Epithelial-to-mesenchymal transition (EMT) has been implicated in various physiological
and pathological events. In this study, we found that the synthetic glucocorticoid …