Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer
RC Bruntz, CW Lindsley, HA Brown, DR Sibley - Pharmacological reviews, 2014 - Elsevier
Phospholipase D is a ubiquitous class of enzymes that generates phosphatidic acid as an
intracellular signaling species. The phospholipase D superfamily plays a central role in a …
intracellular signaling species. The phospholipase D superfamily plays a central role in a …
Collapsin response mediator proteins (CRMPs) Involvement in nervous system development and adult neurodegenerative disorders
E Charrier, S Reibel, V Rogemond, M Aguera… - Molecular …, 2003 - Springer
The members of the collapsin response mediator protein (CRMP) family—five cytosolic
phosphoproteins—are highly expressed throughout brain development. The first member to …
phosphoproteins—are highly expressed throughout brain development. The first member to …
Semaphorin junction: making tracks toward neural connectivity
RJ Pasterkamp, AL Kolodkin - Current opinion in neurobiology, 2003 - Elsevier
Semaphorins constitute one of the largest families of repulsive and attractive growth cone
guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with …
guidance proteins. They affect the growth cone's actin cytoskeleton through interactions with …
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation
Y Kawano, T Yoshimura, D Tsuboi… - … and cellular biology, 2005 - Am Soc Microbiol
A neuron has two types of highly polarized cell processes, the single axon and multiple
dendrites. One of the fundamental questions of neurobiology is how neurons acquire such …
dendrites. One of the fundamental questions of neurobiology is how neurons acquire such …
The CRMP family of proteins and their role in Sema3A signaling
EF Schmidt, SM Strittmatter - Semaphorins: receptor and intracellular …, 2007 - Springer
The CRMP proteins were originally identified as mediators of Sema3A signaling and
neuronal differentiation. Much has been learned about the mechanism by which CRMPs …
neuronal differentiation. Much has been learned about the mechanism by which CRMPs …
Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners
Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates
phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular …
phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular …
α2-Chimaerin, cyclin-dependent kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone …
M Brown, T Jacobs, B Eickholt, G Ferrari… - Journal of …, 2004 - Soc Neuroscience
Neurite outgrowth is influenced by positive and negative signals that include the
semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac …
semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac …
Mammalian phospholipase D: Function, and therapeutics
Despite being discovered over 60 years ago, the precise role of phospholipase D (PLD) is
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
Structural bases for CRMP function in plexin‐dependent semaphorin3A signaling
RC Deo, EF Schmidt, A Elhabazi, H Togashi… - The EMBO …, 2004 - embopress.org
Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in
neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the …
neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the …
Structure and regulation of human phospholipase D
Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary
messenger involved with a broad spectrum of cellular functions including but not limited to …
messenger involved with a broad spectrum of cellular functions including but not limited to …