The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

The brain exhibits a complex temporal structure which translates into a hierarchy of distinct
neural timescales. An open question is how these intrinsic timescales are related to sensory …

Amyotrophic lateral sclerosis is a devastating disease characterized primarily by motor
system degeneration, with clinical evidence of cognitive and behavioural change in up to …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily
affecting motor function, with additional evidence of extensive nonmotor involvement …

Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …

A summit held March 2023 in Scottsdale, Arizona (USA) focused on the intronic
hexanucleotide expansion in the C9ORF72 gene and its relevance in frontotemporal …

Advances in neuroimaging, complementing histopathological insights, have established a
multi-system involvement of cerebral networks beyond the traditional neuromuscular …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative, clinically
heterogeneous syndrome pathologically overlapping with frontotemporal dementia. To date …

This study hypothesizes that the brain shows hyper connectedness as amyotrophic lateral
sclerosis (ALS) progresses. 54 patients (classified as “early stage” or “advanced stage”) and …