Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Chronic pain resulting from nerve injury, tissue inflammation, and tumor invasion or
treatment, is a major health problem impacting the quality of life and producing a significant …

Neuroinflammation is a major component in the transition to and perpetuation of neuropathic
pain states. Spinal neuroinflammation involves activation of TLR4, localized to enlarged …

Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including …

Background Despite the increasing knowledge of the etiology of neuropathic pain, this type
of chronic pain is resistant to available analgesics in approximately 50% of patients and …

Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …

Brain cancer and leukemia are the most common cancers diagnosed in the pediatric
population and are often treated with lifesaving chemotherapy. However, chemotherapy …

Background Cannabidiol (CBD) is one of the main phytocannabinoids found in Cannabis
sativa. In contrast to Δ9-tetrahydrocannabinol, it has a low affinity for cannabinoid receptors …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-
limiting side effect of many chemotherapy regimens yet has limited treatments due to …