Development of chimpanzee adenoviruses as vaccine vectors: challenges and successes emerging from clinical trials
S Capone, AM D'Alise, V Ammendola… - Expert review of …, 2013 - Taylor & Francis
Replication-defective chimpanzee adenovirus vectors are emerging as a promising new
class of genetic vaccine carriers. Chimpanzee adenovirus vectors have now reached the …
class of genetic vaccine carriers. Chimpanzee adenovirus vectors have now reached the …
[HTML][HTML] Construction and application of adenoviral vectors
H Zhang, H Wang, Y An, Z Chen - Molecular Therapy. Nucleic …, 2023 - ncbi.nlm.nih.gov
Adenoviral vectors have been widely used as vaccine candidates or potential vaccine
candidates against infectious diseases due to the convenience of genome manipulation …
candidates against infectious diseases due to the convenience of genome manipulation …
Seroprevalence of neutralizing antibodies to human adenoviruses type‐5 and type‐26 and chimpanzee adenovirus type‐68 in healthy Chinese adults
S Zhang, W Huang, X Zhou, Q Zhao… - Journal of medical …, 2013 - Wiley Online Library
Replication‐defective adenoviruses have been utilized as candidate vaccine vectors.
However, clinical application of the best‐studied human adenovirus type‐5 (AdHu5) is …
However, clinical application of the best‐studied human adenovirus type‐5 (AdHu5) is …
[HTML][HTML] Neutralizing antibodies to human and simian adenoviruses in humans and New-World monkeys
J Ersching, MIM Hernandez, FS Cezarotto… - Virology, 2010 - Elsevier
Vaccines based on adenovirus (Ad) vectors are currently in development against several
pathogens. However, neutralizing antibodies (NAb) to human adenovirus type 5 (AdHu5) …
pathogens. However, neutralizing antibodies (NAb) to human adenovirus type 5 (AdHu5) …
Adenovirus vector‐based prime‐boost vaccination via heterologous routes induces cervicovaginal CD8+ T cell responses against HPV16 oncoproteins
N Cuburu, S Khan, CD Thompson… - … journal of cancer, 2018 - Wiley Online Library
Recent advances in immunotherapy against cancer underscore the importance of T
lymphocytes and tumor microenvironment, but few vaccines targeting cancer have been …
lymphocytes and tumor microenvironment, but few vaccines targeting cancer have been …
Quality of the transgene-specific CD8+ T cell response induced by adenoviral vector immunization is critically influenced by virus dose and route of vaccination
PJ Holst, C Ørskov, AR Thomsen… - The Journal of …, 2010 - journals.aai.org
Adenoviral vectors have been widely used for experimental gene therapy and vaccination,
yet there is a surprising lack of knowledge connecting the route and dose of adenovirus …
yet there is a surprising lack of knowledge connecting the route and dose of adenovirus …
Engineering intravaginal vaccines to overcome mucosal and epithelial barriers
Z Ji, Z Xie, Z Zhang, T Gong, X Sun - Biomaterials, 2017 - Elsevier
The mucosal surface of the vagina is a primary human immunodeficiency virus (HIV) entry
portal, making it an attractive site for HIV vaccination. However, HIV vaccines based on …
portal, making it an attractive site for HIV vaccination. However, HIV vaccines based on …
Novel vaccination protocol with two live mucosal vectors elicits strong cell-mediated immunity in the vagina and protects against vaginal virus challenge
Most HIV infections result from heterosexual transmission to women. Because cellular
immunity plays a key role in the control of the infection, we sought to strengthen cellular …
immunity plays a key role in the control of the infection, we sought to strengthen cellular …
Quillaja brasiliensis saponins induce robust humoral and cellular responses in a bovine viral diarrhea virus vaccine in mice
SP Cibulski, F Silveira, G Mourglia-Ettlin… - … and Infectious Diseases, 2016 - Elsevier
A saponin fraction extracted from Quillaja brasiliensis leaves (QB-90) and a semi-purified
aqueous extract (AE) were evaluated as adjuvants in a bovine viral diarrhea virus (BVDV) …
aqueous extract (AE) were evaluated as adjuvants in a bovine viral diarrhea virus (BVDV) …
Intramuscular rather than oral administration of replication-defective adenoviral vaccine vector induces specific CD8+ T cell responses in the gut
SW Lin, AS Cun, K Harris-McCoy, HC Ertl - Vaccine, 2007 - Elsevier
Gut-associated lymphoid tissue (GALT) is the primary replication site for HIV-1, resulting in a
pronounced CD4+ T cell loss in this tissue during primary infection. A mucosal vaccine that …
pronounced CD4+ T cell loss in this tissue during primary infection. A mucosal vaccine that …