Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Atherosclerotic vascular disease (ASVD) is the leading cause of death worldwide.
Hyperuricemia is the fourth risk factor for atherosclerosis after hypertension, diabetes, and …

Skeletal muscle is the most abundant type of tissue in human body, being involved in
diverse activities and maintaining a finely tuned metabolic balance. Autophagy …

Glucocorticoid receptor (GR) belongs to the superfamily of steroid hormone receptors. The
dissociated or selective GR modulators (SEGRMs), preferring the transrepression rather …

The molecular mechanisms of cytokine storm in patients with severe COVID-19 infections
are poorly understood. To uncover these events, we performed transcriptome analyses of …

Inflammation represents a fundamental immune response triggered by various detrimental
stimuli, such as infections, tissue damage, toxins, and foreign substances. Protein …

Glucocorticoids (GCs) are known potent clinical drugs, however, their mode of action is still
complex and debatable. Macrophages are the most important target of GCs and play a key …

Abstract Ethnopharmacological relevance Dachaihu Decoction (DD), a classic Chinese
herbal prescription, is composed of radix of Bupleurum chinense DC.(Chaihu), radix of …