Visual phototransduction is the most extensively studied G protein-coupled receptor (GPCR)
signaling pathway because of its quantifiable stimulus, non-redundancy of genes, and …

Functional compartmentalization of cells is a universal strategy for segregating processes
that require specific components, undergo regulation by modulating concentrations of those …

Among cyclic nucleotide phosphodiesterases (PDEs), PDE6 is unique in serving as an
effector enzyme in G protein-coupled signal transduction. In retinal rods and cones, PDE6 is …

Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D
(PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human …

Retinal photoreceptors are neurons that convert dynamically changing patterns of light into
electrical signals that are processed by retinal interneurons and ultimately transmitted to …

Photoreceptors are polarized neurons, with specific subcellular compartmentalization and
unique requirements for protein expression and trafficking. Each photoreceptor contains an …

Rod photoreceptor phosphodiesterase (PDE6) is the key catalytic enzyme of visual
phototransduction. PDE6 is the only member of the phosphodiesterase family that consists …

The use of natural products as potential ligands has been explored as a strategy in the
development of metal-based chemotherapy. Since ruthenium complexes are promising …

G protein interacting protein 1 (Gip1) binds and sequesters heterotrimeric G proteins in the
cytosolic pool, thus regulating G protein-coupled receptor (GPCR) signalling for eukaryotic …

Cytoskeletal reorganization driven by Rho GTPases plays a crucial role in the migration of T
cells, which are key regulators of immunity. The molecular mechanisms that control actin …