Gold compounds have a long history of use in medicine. Auranofin was developed more
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …

Leishmaniasis is a neglected tropical disease caused by a protozoan species of the genus
Leishmania affecting mostly the developing countries. The disease with current mortality rate …

Drug discovery, development and registration is an expensive and time-consuming process
associated with a high failure rate [Pessetto et al.(Mol Cancer Ther 12: 1299–1309, 2013) …

Entamoeba histolytica, a protozoan intestinal parasite, is the causative agent of human
amebiasis. Amebiasis is the fourth leading cause of death and the third leading cause of …

Under an NIH priority to identify new drugs to treat class B parasitic agents, we performed
high-throughput screens, which identified the activity of auranofin (Ridaura) against …

Selenium is an essential trace element in mammals. The major biological form of this
micronutrient is the amino acid selenocysteine, which is present in the active sites of …

Project: This study investigated the in vitro and in vivo effectiveness of biogenic selenium
nanoparticles (Se NPs), biosynthesized by Bacillus sp. MSh-1, against Leishmania major …

Giardiasis is one of the most common causes of diarrheal disease worldwide. Treatment is
primarily with 5-nitro antimicrobials, particularly metronidazole. Resistance to metronidazole …

BACKGROUND: The amino acid selenocysteine (Sec) is the major biological form of the
trace element selenium. Sec is co-translationally incorporated in selenoproteins. There are …

Cystic echinococcosis (hydatid cyst, CE) as a zoonotic parasitic infection caused by the
larval stage of the dog tapeworm Echinococcus granulosus is still an important economic …