Genome editing offers promising solutions to genetic disorders by editing DNA sequences
or modulating gene expression. The clustered regularly interspaced short palindromic …

Background Technologies for making and manipulating DNA have enabled advances in
biology ever since the discovery of the DNA double helix. But introducing site-specific …

Background The success of the CRISPR/Cas9 genome editing technique depends on the
choice of the guide RNA sequence, which is facilitated by various websites. Despite the …

Epigenetic studies relied so far on correlations between epigenetic marks and gene
expression pattern. Technologies developed for epigenome editing now enable direct study …

Large genome-mapping consortia and thousands of genome-wide association studies have
identified non-protein-coding elements in the genome as having a central role in various …

The adaptive immunity system in bacteria and archaea, Clustered Regularly Interspaced
Short Palindromic Repeats, CRISPR-associate (CRISPR/Cas), has been adapted as a …

We present Cas-Designer, a user-friendly program to aid researchers in choosing
appropriate target sites in a gene of interest for type II CRISPR/Cas-derived RNA-guided …

Genome editing reemerged in 2012 with the development of CRISPR/Cas9 technology,
which is a genetic manipulation tool derived from the defense system of certain bacteria …

Genome-editing, a recent technological advancement in the field of life sciences, is one of
the great examples of techniques used to explore the understanding of the biological …

Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR‐associated
protein (Cas) 9‐mediated genome modification enables us to edit the genomes of a variety …