Yeast two-hybrid approaches, which are based on fusion proteins that must co-localise to
the nucleus to reconstitute the transcriptional activity of GAL4, have greatly contributed to our …

In eukaryotes, chromosomal DNA is equally distributed to daughter cells during mitosis,
whereas the number of chromosomes is halved during meiosis. Despite considerable …

Pre-mRNA splicing plays a fundamental role in securing protein diversity by generating
multiple transcript isoforms from a single gene. Recently, it has been shown that specific G …

Viruses hijack host proteins to promote infection and dampen host defenses. Adenovirus
encodes the multifunctional protein VII that serves both to compact viral genomes inside the …

Many cellular processes require the activities of complex molecular machines composed of
several protein subunits. Insights into these systems can be gained by isolation of protein …