Neurotransmitters are released by synaptic vesicle exocytosis at the active zone of a
presynaptic nerve terminal. In this review, I discuss the molecular composition and function …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly
understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human …

The intracellular calcium concentration ([Ca 2+]) has important roles in the triggering of
neurotransmitter release and the regulation of short-term plasticity (STP). Transmitter …

SNARE proteins have been proposed to mediate all intracellular membrane fusion events.
There are over 30 SNARE family members in mammalian cells and each is found in a …

Secretion of cytolytic granules content at the immunological synapse is a highly regulated
process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of …

The weight of synaptic connections, which is controlled not only postsynaptically but also
presynaptically, is a key determinant in neuronal network dynamics. The mechanisms …

Neurotransmitter release at synapses between nerve cells is mediated by calcium-triggered
exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at the presynaptic release …

We analyzed the synaptic physiology of unc-13 mutants in the nematode C. elegans.
Mutants of unc-13 had normal nervous system architecture, and the densities of synapses …

Synaptic vesicles must be primed to fusion competence before they can fuse with the
plasma membrane in response to increased intracellular Ca2+ levels. The presynaptic …