The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

During limb development, digits emerge from the undifferentiated mesenchymal tissue that
constitutes the limb bud. It has been proposed that this process is controlled by a self …

The formation of repetitive structures (such as stripes) in nature is often consistent with a
reaction-diffusion mechanism, or Turing model, of self-organizing systems. We used mouse …

During embryonic development, digits gradually emerge in a periodic pattern. Although
genetic evidence indicates that digit formation results from a self-organizing process, the …

The vertebrate body is made by progressive addition of new tissue from progenitors at the
posterior embryonic end. Axial extension involves different mechanisms that produce …

Initial limb chondrogenesis offers the first differentiated tissues that resemble the mature
skeletal anatomy. It is a developmental progression of three tissues. The limb begins with …

Embryonic tissues are shaped by the dynamic behaviours of their constituent cells. To
understand such cell behaviours and how they evolved, new approaches are needed to …

The house mouse, Mus musculus, is an exceptional model system, combining genetic
tractability with close homology to human biology. Gestation in mouse development lasts …

After more than a century of research, the mouse remains the gold-standard model system,
for it recapitulates human development and disease and is quickly and highly tractable to …

The distal part of the tetrapod limb, the autopod, is characterized by the presence of digits.
The digits display a wide diversity of shapes and number reflecting selection pressure for …