Systemic immunoglobulin light chain amyloidosis
G Merlini, A Dispenzieri, V Sanchorawala… - Nature reviews Disease …, 2018 - nature.com
Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by
the conversion of immunoglobulin light chains from their soluble functional states into highly …
the conversion of immunoglobulin light chains from their soluble functional states into highly …
AL amyloidosis: from molecular mechanisms to targeted therapies
G Merlini - Hematology 2014, the American Society of …, 2017 - ashpublications.org
Systemic amyloidosis is caused by misfolding and extracellular deposition of circulating
proteins as amyloid fibrils, resulting in the dysfunction of vital organs. The most common …
proteins as amyloid fibrils, resulting in the dysfunction of vital organs. The most common …
Label-Free High-Resolution Photothermal Optical Infrared Spectroscopy for Spatiotemporal Chemical Analysis in Fresh, Hydrated Living Tissues and Embryos
Label-free chemical imaging of living and functioning systems is the holy grail of
biochemical research. However, existing techniques often require extensive sample …
biochemical research. However, existing techniques often require extensive sample …
[HTML][HTML] Prion-like seeding and nucleation of intracellular amyloid-β
TT Olsson, O Klementieva, GK Gouras - Neurobiology of disease, 2018 - Elsevier
Alzheimer's disease (AD) brain tissue can act as a seed to accelerate aggregation of
amyloid-β (Aβ) into plaques in AD transgenic mice. Aβ seeds have been hypothesized to …
amyloid-β (Aβ) into plaques in AD transgenic mice. Aβ seeds have been hypothesized to …
Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP
O Klementieva, K Willén, I Martinsson… - Nature …, 2017 - nature.com
Reducing levels of the aggregation-prone Aβ peptide that accumulates in the brain with
Alzheimer's disease (AD) has been a major target of experimental therapies. An alternative …
Alzheimer's disease (AD) has been a major target of experimental therapies. An alternative …
The association of lipids with amyloid fibrils
JM Sanderson - Journal of Biological Chemistry, 2022 - ASBMB
Amyloid formation continues to be a widely studied area due to its association with
numerous diseases, such as Alzheimer's and Parkinson's diseases. Despite a large body of …
numerous diseases, such as Alzheimer's and Parkinson's diseases. Despite a large body of …
Contribution of infrared spectroscopy to the understanding of amyloid protein aggregation in complex systems
Infrared (IR) spectroscopy is a label-free and non-invasive technique that probes the
vibrational modes of molecules, thus providing a structure-specific spectrum. The …
vibrational modes of molecules, thus providing a structure-specific spectrum. The …
Inflammatory bowel disease induces pathological α‐synuclein aggregation in the human gut and brain
Abstract Aims According to Braak's hypothesis, it is plausible that Parkinson's disease (PD)
originates in the enteric nervous system (ENS) and spreads to the brain through the vagus …
originates in the enteric nervous system (ENS) and spreads to the brain through the vagus …
Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues
LW Simpson, TA Good, JB Leach - Biotechnology advances, 2020 - Elsevier
In the biological milieu of a cell, soluble crowding molecules and rigid confined
environments strongly influence whether the protein is properly folded, intrinsically …
environments strongly influence whether the protein is properly folded, intrinsically …
Pathophysiological response to SARS-CoV-2 infection detected by infrared spectroscopy enables rapid and robust saliva screening for COVID-19
Fourier transform infrared (FTIR) spectroscopy provides a (bio) chemical snapshot of the
sample, and was recently used in proof-of-concept cohort studies for COVID-19 saliva …
sample, and was recently used in proof-of-concept cohort studies for COVID-19 saliva …