Abstract SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the
SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in …

Keloids are a fibroproliferative skin disorder that develops in people of all ages. Keloids
exhibit some cancer-like behaviors, with similar genetic and epigenetic modifications in the …

Poor wound healing and pathological healing have been pressing issues in recent years, as
they impact human quality of life and pose risks of long-term complications. The study of …

Research on keloid is limited by the lack of proper in vitro and animal model reflecting in
vivo status. Based on heterogeneity of keloid and important role of endothelial cells in its …

Hypertrophic scar (HTS) formation is a common challenge for patients after burn injury.
Dermal microvascular endothelial cells (DMVECs) are an understudied cell type in HTS. An …

Background Breast cancer is strongly influenced by hereditary risk factors. Yet, the known
susceptibility genes and genomic loci explain only about half of the familial component of …

Background The autophagy adapter SQSTM1/p62 is crucial for maintaining homeostasis in
various organs and cells due to its protein–protein interaction domains and involvement in …

miRNAs are small noncoding RNAs that regulate mRNA targets in a cell-specific manner.
miR-29 is expressed in murine and human skin, where it may regulate functions in skin …

Early-onset colorectal cancer (EOCRC), recognized as a distinct subgroup with an
increased incidence over the past two decades, characterized by its aggressive nature and …

Recently, the pathomechanisms of keloids have been extensively researched using
transcriptomic analysis, but most studies did not consider the activity of keloids. We aimed to …