The most competent plant-derived natural products for targeting apoptosis in cancer therapy

S Rajabi, M Maresca, AV Yumashev, R Choopani… - Biomolecules, 2021 - mdpi.com
Cancer is a challenging problem for the global health community, and its increasing burden
necessitates seeking novel and alternative therapies. Most cancers share six basic …

[HTML][HTML] Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice

Y Zhang, X Yang, X Ge, F Zhang - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Background Subarachnoid hemorrhage (SAH) results in many brain dysfunctions and the
neuroprotective function of puerarin after brain damage has been demonstrated in several …

Phytoconstituents as apoptosis inducing agents: strategy to combat cancer

M Kumar, V Kaur, S Kumar, S Kaur - Cytotechnology, 2016 - Springer
Advancement in the field of cancer molecular biology has aided researchers to develop
various new chemopreventive agents which can target cancer cells exclusively. Cancer …

[HTML][HTML] Is Bax/Bcl-2 ratio considered as a prognostic marker with age and tumor location in colorectal cancer?

E Khodapasand, N Jafarzadeh, F Farrokhi… - Iranian biomedical …, 2015 - ncbi.nlm.nih.gov
Background: Bax and Bcl-2 are the major members of Bcl-2 family whose play a key role in
tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial …

Eco-friendly formulated zinc oxide nanoparticles: induction of cell cycle arrest and apoptosis in the MCF-7 cancer cell line

A Boroumand Moghaddam, M Moniri, S Azizi… - Genes, 2017 - mdpi.com
Green products have strong potential in the discovery and development of unique drugs.
Zinc oxide nanoparticles (ZnO NPs) have been observed to have powerful cytotoxicity …

The potential mechanism of histamine-inducing cardiopulmonary inflammation and apoptosis in a novel oral model of rat intoxication

EI Hassanen, S Kamel, WA Mohamed, HA Mansour… - Toxicology, 2023 - Elsevier
Histamine (HIS) is a potent vasodilator that contributes to anaphylactic reactions. Our
investigation aims to study the possible toxic impact of repeated oral administration of …

Modulation of histone deacetylase, the ubiquitin proteasome system, and autophagy underlies the neuroprotective effects of venlafaxine in a rotenone-induced …

KA El-Saiy, RH Sayed, AE El-Sahar… - Chemico-Biological …, 2022 - Elsevier
Parkinson's disease (PD) is a neurodegenerative disease characterized by motor and non-
motor symptoms. Impairment of the ubiquitin proteasome system (UPS) and autophagy has …

Mitochondrial targeted cerium oxide nanoclusters for radiation protection and promoting hematopoiesis

L Yang, H Ran, Y Yin, J Liu, B Lu, X Ran… - International Journal …, 2024 - Taylor & Francis
Purpose Mitochondrial oxidative stress is an important factor in cell apoptosis. Cerium oxide
nanomaterials show great potential for scavenging free radicals and simulating superoxide …

Flavonoids of Rosa roxburghii Tratt exhibit radioprotection and anti-apoptosis properties via the Bcl-2(Ca2+)/Caspase-3/PARP-1 pathway

P Xu, X Cai, W Zhang, Y Li, P Qiu, D Lu, X He - Apoptosis, 2016 - Springer
The objective of our study was to assess the radioprotective effect of flavonoids extracted
from Rosa roxburghii Tratt (FRT) and investigate the role of Bcl-2 (Ca 2+)/Caspase-3/PARP …

Preparation and evaluation of gastrodin microsphere-loaded Gastrodia elata polysaccharides composite hydrogel on UVB-induced skin damage in vitro and in vivo

W Yu, Y Zhao, P Jia, W Liu, Z Cheng, W Li… - International Journal of …, 2024 - Elsevier
Skin damage from sun exposure is a common issue among outdoor workers and is primarily
caused by ultraviolet rays. Upon absorption of these rays, the skin will experience …