Areas of controversy in neuroprogression in bipolar disorder

IC Passos, B Mwangi, E Vieta, M Berk… - Acta Psychiatrica …, 2016 - Wiley Online Library
Objective We aimed to review clinical features and biological underpinnings related to
neuroprogression in bipolar disorder (BD). Also, we discussed areas of controversy and …

Clinical implications of a staging model for bipolar disorders

F Kapczinski, VV Dias, M Kauer-Sant'Anna… - Expert review of …, 2009 - Taylor & Francis
A model of staging in the field of bipolar disorder (BD) should offer a means for clinicians to
predict response to treatment and more general outcome measures, such as the level of …

Structural magnetic resonance imaging in bipolar disorder: an international collaborative mega-analysis of individual adult patient data

B Hallahan, J Newell, JC Soares, P Brambilla… - Biological …, 2011 - Elsevier
BACKGROUND:: There is substantial inconsistency in results of brain structural magnetic
resonance imaging studies in adult bipolar disorder. This is likely consequent upon limited …

Preclinical and clinical evidence of antioxidant effects of antidepressant agents: implications for the pathophysiology of major depressive disorder

GA Behr, JCF Moreira, BN Frey - Oxidative medicine and …, 2012 - Wiley Online Library
Major depressive disorder (MDD) is a common mental disorder associated with a significant
negative impact on quality of life, morbidity/mortality, and cognitive function. Individuals who …

Lithium as a neuroprotective agent for bipolar disorder: an overview

ELM Ochoa - Cellular and molecular neurobiology, 2022 - Springer
Lithium (Li+) is a first option treatment for adult acute episodes of Bipolar Disorder (BD) and
for the prophylaxis of new depressed or manic episodes. It is also the preferred choice as …

Neuroprogression in bipolar disorder

MR Schneider, MP DelBello, RK McNamara… - Bipolar …, 2012 - Wiley Online Library
Schneider MR, DelBello MP, McNamara RK, Strakowski SM, Adler CM. Neuroprogression in
bipolar disorder. Bipolar Disord 2012: 14: 356–374.© 2012 The Authors. Journal …

Toward precision psychiatry in bipolar disorder: staging 2.0

E Salagre, S Dodd, A Aedo, A Rosa, S Amoretti… - Frontiers in …, 2018 - frontiersin.org
Personalized treatment is defined as choosing the “right treatment for the right person at the
right time.” Although psychiatry has not yet reached this level of precision, we are on the way …

Inflammatory mediators of cognitive impairment in bipolar disorder

IE Bauer, MC Pascoe, B Wollenhaupt-Aguiar… - Journal of psychiatric …, 2014 - Elsevier
Objectives Recent studies have pointed to neuroinflammation, oxidative stress and
neurotrophic factors as key mediators in the pathophysiology of mood disorders. Little is …

Can the retinal ganglion cell layer (GCL) volume be a new marker to detect neurodegeneration in bipolar disorder?

A Kalenderoglu, A Sevgi-Karadag, M Celik… - Comprehensive …, 2016 - Elsevier
Purpose The aim of this study was to compare the ganglion cell layer (GCL) volume and
retinal nerve fiber layer (RNFL) thickness in bipolar patients and controls using optic …

Altered resting-state cerebral blood flow and functional connectivity of striatum in bipolar disorder and major depressive disorder

Z He, W Sheng, F Lu, Z Long, S Han, Y Pang… - Progress in Neuro …, 2019 - Elsevier
Background Clinically distinguishing bipolar disorder (BD) from major depressive disorder
(MDD) during depressive states is difficult. Neuroimaging findings suggested that patients …