Emerging class of omega-3 fatty acid endocannabinoids & their derivatives

JE Watson, JS Kim, A Das - Prostaglandins & other lipid mediators, 2019 - Elsevier
Cannabinoid receptor activation is involved in homeostatic regulation of the body. These
receptors are activated by cannabinoids, that include the active constituents of Cannabis …

N-Docosahexaenoylethanolamine: A neurotrophic and neuroprotective metabolite of docosahexaenoic acid

HY Kim, AA Spector - Molecular aspects of medicine, 2018 - Elsevier
N-Docosahexaenoylethanolamine (synaptamide) is an endocannabinoid-like metabolite
endogenously synthesized from docosahexaenoic acid (DHA, 22: 6n-3), the major omega-3 …

Marine natural products from the Russian Pacific as sources of drugs for neurodegenerative diseases

YS Khotimchenko, DN Silachev, VL Katanaev - Marine Drugs, 2022 - mdpi.com
Neurodegenerative diseases are growing to become one of humanity's biggest health
problems, given the number of individuals affected by them. They cause enough mortalities …

Molecular and signaling mechanisms for docosahexaenoic acid-derived neurodevelopment and neuroprotection

HY Kim, BX Huang, AA Spector - International Journal of Molecular …, 2022 - mdpi.com
The neurodevelopmental and neuroprotective actions of docosahexaenoic acid (DHA) are
mediated by mechanisms involving membrane-and metabolite-related signal transduction. A …

Structured form of DHA prevents neurodegenerative disorders: A better insight into the pathophysiology and the mechanism of DHA transport to the brain

J Balakrishnan, S Kannan, A Govindasamy - Nutrition Research, 2021 - Elsevier
Docosahexaenoic acid (DHA) is one of the most important fatty acids that plays a critical role
in maintaining proper brain function and cognitive development. Deficiency of DHA leads to …

Anti-inflammatory activity of synaptamide in the peripheral nervous system in a model of sciatic nerve injury

A Starinets, A Tyrtyshnaia, I Manzhulo - International Journal of Molecular …, 2023 - mdpi.com
N-docosahexaenoylethanolamine (DHEA), or synaptamide, is an endogenous metabolite of
docosahexaenoic acid (DHA) that exhibits synaptogenic and neurogenic effects. In our …

N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats

AI Ponomarenko, AA Tyrtyshnaia, EA Pislyagin… - Scientific Reports, 2021 - nature.com
At present, there is a growing interest in the study of the neurotropic activity of
polyunsaturated fatty acids ethanolamides (N-acylethanolamines). N …

Synaptamide improves cognitive functions and neuronal plasticity in neuropathic pain

A Tyrtyshnaia, A Bondar, S Konovalova… - International journal of …, 2021 - mdpi.com
Neuropathic pain arises from damage or dysfunction of the peripheral or central nervous
system and manifests itself in a wide variety of sensory symptoms and cognitive disorders …

Anti-inflammatory and anti-apoptotic activity of synaptamide improves the morphological state of neurons in traumatic brain injury

I Manzhulo, A Tyrtyshnaia, A Egoraeva… - …, 2024 - Elsevier
Traumatic brain injuries (TBI) of varying severity are becoming more frequent all over the
world. The process of neuroinflammation, in which macrophages and microglia are key …

Omega-3 polyunsaturated fatty acids in the brain and visual system: Focus on invertebrates

E Fock, R Parnova - Comparative Biochemistry and Physiology Part B …, 2024 - Elsevier
A critical role of omega-3 polyunsaturated fatty acids (PUFA), mainly docosahexaenoic acid
22: 6ω3 (DHA), in the development and function of the brain and visual system is well …