A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

The MTT assay for cellular metabolic activity is almost ubiquitous to studies of cell toxicity;
however, it is commonly applied and interpreted erroneously. We investigated the …

Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and
mammalian target of rapamycin (mTOR) constitute the core components of the …

Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by
uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell …

The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells,
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …

Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes
and tumor suppressors, leading to the constitutive activation of signaling pathways involved …

Cancer is driven by genetic and epigenetic alterations that allow cells to overproliferate and
escape mechanisms that normally control their survival and migration. Many of these …

Stress-signaling pathways are evolutionarily conserved and play an important role in the
maintenance of homeostasis. These pathways are also critical for adaptation to new cellular …