Living species are continuously subjected to all extrinsic forms of reactive oxidants and
others that are produced endogenously. There is extensive literature on the generation and …

Reactive oxygen species (ROS), natural by-products of aerobic respiration, are important
cell signaling molecules, which left unchecked can severely impair cellular functions and …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Mitochondrial uncoupling proteins (UCP) 1-3 fulfill many physiological functions, ranging
from non-shivering thermogenesis (UCP1) to glucose-stimulated insulin release (GSIS) and …

Altered cellular metabolism is a defining feature of cancer [1]. The best studied metabolic
phenotype of cancer is aerobic glycloysis–also known as the Warburg effect–characterized …

The oncogenic KRAS mutation has a critical role in the initiation of human pancreatic ductal
adenocarcinoma (PDAC) since it rewires glutamine metabolism to increase reduced …

One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the
laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic …

Evidence suggests that mitochondrial metabolism may play a key role in controlling cancer
cells life and proliferation. Recent evidence also indicates how the altered contribution of …

To defend against a vast variety of challenges in oxygenated environments, all life forms
have evolutionally established a set of antioxidants, detoxification, and cytoprotective …

Despite the international scientific community's commitment to improve clinical knowledge
about coronavirus disease 2019 (COVID‐19), knowledge regarding molecular details …