A major subset of human cancers shows evidence for spontaneous adaptive immunity,
which is reflected by the presence of infiltrating CD8+ T cells specific for tumor antigens …

A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be
predictive for response to contemporary cancer immunotherapies. The generation of a …

Vaccination is one of the most efficient strategies for the prevention of infectious diseases.
Although safer, subunit vaccines are poorly immunogenic and for this reason the use of …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics
Toward precision adjuvants: optimizing science and safety : Current Opinion in Pediatrics Log …

Background Newborns display distinct immune responses, leaving them vulnerable to
infections and impairing immunization. Targeting newborn dendritic cells (DCs), which …

The discovery of the TLRs family and more precisely its functions opened a variety of gates
to modulate immunological host responses. TLRs 7/8 are located in the endosomal …

The need for new adjuvants is absolutely cardinal to the development of new vaccines and
to further optimizing current immunization approaches. However, only a few classes of …

Chronic inflammation in the tumor microenvironment and evasion of the antitumor effector
immune response are two of the emerging hallmarks required for oncogenesis and cancer …

Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …