Cdk5 is a proline-directed serine/threonine protein kinase that governs a variety of cellular
processes in neurons, the dysregulation of which compromises normal brain function. The …

In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few
of these kinases are currently known to enable learning and memory. Based on this …

Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various
neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of …

Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of
the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an …

Alzheimer's disease (AD) is a mostly sporadic brain disorder characterized by cognitive
decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex …

The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB participate
in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial …

Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which
account for 55% of all neurological diseases, are the leading cause of permanent disability …

Whether mild cognitive impairment (MCI) has a distinct neuropathological profile that reflects
an intermediate state between no cognitive impairment and dementia is not clear. Identifying …

Abstract Cyclin-dependent kinase 5 (Cdk5) is a peculiar proline-directed serine/threonine
kinase. Unlike the other members of the Cdk family, Cdk5 is not directly involved in cell cycle …

Adolescence represents a crucial phase of synaptic maturation characterized by molecular
changes in the developing brain that shape normal behavioral patterns. Epigenetic …