Diffusion is a pervasive process present in a broad spectrum of cellular reactions. Its
mathematical description has existed for nearly two centuries and permits the construction of …

The dynamics of enzymes are directly associated with their functions in various biological
processes. Nevertheless, the ability to image motions of single enzymes in a highly parallel …

Ras is a membrane-anchored signaling protein that serves as a hub for many signaling
pathways and also plays a prominent role in cancer. The intrinsic behavior of Ras on the …

In chemotaxing ameboid cells, a complex leading-edge signaling circuit forms on the
cytoplasmic leaflet of the plasma membrane and directs both actin and membrane …

Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated
by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate …

The chemotactic migration of eukaryotic ameboid cells up concentration gradients is among
the most advanced forms of cellular behavior. Chemotaxis is controlled by a complex …

Peripheral membrane proteins bound to lipids on bilayer surfaces play central roles in a
wide array of cellular processes, including many signaling pathways. These proteins diffuse …

Cell division, endocytosis, and viral budding would not function without the localization and
assembly of protein complexes on membranes. What is poorly appreciated, however, is that …

Cells self-organize using reaction-diffusion and fluid-flow principles. Whether bulk
membrane flows contribute to cell patterning has not been established. Here, using …

Membrane-targeting domains play crucial roles in the recruitment of signalling molecules to
the plasma membrane. For most peripheral proteins, the protein-to-membrane interaction is …