Current and emerging therapies for corneal neovascularization

D Roshandel, M Eslani, A Baradaran-Rafii… - The ocular …, 2018 - Elsevier
The cornea is unique because of its complete avascularity. Corneal neovascularization
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …

p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle

H Che, J Li, Y Li, C Ma, H Liu, J Qin, J Dong, Z Zhang… - Elife, 2020 - elifesciences.org
The cell cycle regulator p16 is known as a biomarker and an effector of aging. However, its
function in intervertebral disc degeneration (IVDD) is unclear. In this study, p16 expression …

Cellular senescence and ophthalmic diseases: narrative review

M Soleimani, K Cheraqpour, R Koganti… - Graefe's Archive for …, 2023 - Springer
Purpose Cellular senescence is a state of permanent growth arrest whereby a cell reaches
its replicative limit. However, senescence can also be triggered prematurely in certain …

Corneal wound healing effects of mesenchymal stem cell secretome delivered within a viscoelastic gel carrier

GM Fernandes-Cunha, KS Na, I Putra… - Stem cells …, 2019 - academic.oup.com
Severe corneal injuries often result in permanent vision loss and remain a clinical challenge.
Human bone marrow-derived mesenchymal stem cells (MSCs) and their secreted factors …

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye

D Jaishankar, AM Yakoub, T Yadavalli… - Science translational …, 2018 - science.org
Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye
that may advance to corneal blindness. Nucleoside analogs exemplified by acyclovir (ACV) …

[HTML][HTML] Organoids as a model to study intestinal and liver dysfunction in severe malnutrition

JM Horcas-Nieto, CJ Versloot… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Hospitalized children with severe malnutrition face high mortality rates and often suffer from
hepatic and intestinal dysfunction, with negative impacts on their survival. New treatments …

The mTOR signalling in corneal diseases: A recent update

X Li, K Chen, Z Wang, J Li, X Wang, C Xie… - Biochemical …, 2023 - Elsevier
Corneal diseases affect 4.2 million people worldwide and are a leading cause of vision
impairment and blindness. Current treatments for corneal diseases, such as antibiotics …

Therapeutic potential of mesenchymal stem cell-secreted factors on delay in corneal wound healing by nitrogen mustard

S An, X Shen, K Anwar, M Ashraf, H Lee… - International Journal of …, 2022 - mdpi.com
Ocular surface exposure to nitrogen mustard (NM) leads to severe ocular toxicity which
includes the separation of epithelial and stromal layers, loss of endothelial cells, cell death …

Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence

RL Vitar, F Triani, M Barbariga, P Fonteyne, P Rama… - Stem Cell Reports, 2022 - cell.com
Severe ocular surface diseases can lead to limbal stem cell deficiency (LSCD), which is
accompanied by defective healing. We aimed to evaluate the role of the substance P …

UV protection in the cornea: failure and rescue

T Volatier, B Schumacher, C Cursiefen, M Notara - Biology, 2022 - mdpi.com
Simple Summary The sun is a deadly laser, and its damaging rays harm exposed tissues
such as our skin and eyes. The skin's protection and repair mechanisms are well understood …