Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays vital
roles in modulating metabolism, immunity, and oncogenesis. ATF3 acts as a hub of the …

Introduction Ferroptosis is an iron-dependent regulated necrosis and has been proven to
contribute to the progress of acute kidney injury (AKI). Quercetin (QCT), a natural flavonoid …

Antibody production is a metabolically demanding process that is regulated by gut
microbiota, but the microbial products supporting B cell responses remain incompletely …

Monocytes and macrophages provide defence against pathogens and danger signals.
These cells respond to stimulation in a fast and stimulus-specific manner by utilizing …

Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid
accumulation are the most prominent features of atherosclerosis. To understand the …

High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be
protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties …

Cholesterol and components of the cholesterol biosynthetic pathway have fundamental
roles in all mammalian cells. Hydroxylated forms of cholesterol are now emerging as …

Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid
balance between the circulation and surrounding tissues and for preventing the …